This paper introduces a new framework to help build and use SYCL-based Python native extensions. We present the core design and implementation detail of the framework that includes an overview of the API, a technique to support asynchronous SYCL kernel execution via Python, and discussion around the usage of Python extension generator tools to build SYCL-based extensions. Details of ongoing work are presented and we demonstrate the development of a performance portable Python native extension that relies on the SYCL-based oneMKL specification. Speaker: Diptorup Deb (Intel) Co-Authors: Oleksandr Pavlyk (Intel)